There's a new gang war in New York City, but what's a gang war without a Parker caught in the middle? The rivalry between the Kingpin and challenger Canis has heated up, and even Spider-Girl can't end it before the death of a classic Marvel villain! Meanwhile, more villains pop up guided by a mysterious agenda! To them, Spider-Girl's just a troublemaker -- but the Black Tarantula thinks she's destined for more... and for him! Plus, crises at Midtown High! Guest-starring Darkdevil and Kaine the corrupted clone!